Trucheck is a new blood-based paradigm in multicancer detection.
A simple blood test that can detect up to 77 types of cancer, with 99.97% accuracy.
About 4.4 million new cancers are detected every year in Europe as well as about 2 million cancer related deaths. Unfortunately, some cancers are detected at advanced stages which necessitate more intensive and expensive treatments which have greater risk of side effects.
Detection of cancers at early / local stages is vital for successful treatments, lower treatment costs, lower toxicities and improved survival.
Trucheck is the culmination of years of collaborative international research and innovation.
Tested and validated on over
Individuals
Who is Trucheck for
-
Individuals who want to include this into their yearly check-up.
-
Asymptomatic individuals who have a family history of cancer.
-
Asymptomatic individuals who have a high risk of cancer.
Trucheck Advantages
In contrast to screening for a single cancer at a time, TrucheckTM can identify multiple cancer types via a simple blood draw that may be undetectable by present technologies. Detection at earlier stages is associated with greater rates of successful treatment and improved survival.
TrucheckTM intelli interrogates CTCs for the molecular imprint of the tumour mass from where the CTCs originated, i.e., TrucheckTM intelli reveals diagnostically relevant information about the tissue / organ of origin of the tumor with high accuracy. This guides further investigations and reduces diagnostic trial and error.
TrucheckTM is an advanced comprehensive cancer detection that offers an unparalleled combination of sensitivity and specificity for early detection of cancers in asymptomatic individuals.
Sensitivity & Specificity
Clinical validation *
* Preliminary clinical validation of TrucheckTM has been performed in a blinded prospective study involving 15.441 cancers, 700 benign cases and 13.919 asymptomatic individuals to establish the clinical performance characteristics (table above).
Though TrucheckTM is not intended as a replacement for standard of care cancer screening, we benchmarked the clinical performance of TrucheckTM against standard methods to demonstrate its viability and suitability as a primary test which can aid prioritisation of individuals into standard of care screening or detection pathways.
Trucheck™ in colon cancer detection
Trucheck™ in breast cancer detection
Trucheck™ in prostate cancer detection
1. Lehman CD et al. National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr; 283(1): 49-58. doi: 10.1148/radiol.2016161174.
2. PPV and NPV Calculated from data reported by Lehman et al (above).
3. USPSTF reported data.
4. McKiernan J et al. A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High grade Prostate Cancer in Patients with Prostate - specific Antigen 2-10 ng/ml at Initial Biopsy. Eur Urol. 2018 Dec; 74(6):731-738. doi: 10.1016/j. eururo.2018.08.019.
Trucheck Method
CTC enrichment:
-
Conventional means for CTC enrichment have relied upon either immuno-affinity capture (magnetic) or size or charge-based separation (microfluidic devices). The former faces limitations with CTCs that express low amount of epitope or those which are sequestered in clusters with nonepitope expressing cells. In addition to low sensitivity, this also leads to low specificity by enriching incidental non-malignant cells that express the detection epitope.
-
The latter has low capture rate of CTCs beyond the operational size / charge range of the device and can also enrich non-malignant cells with conform to detection parameters. In contrast, TrucheckTM employs an epigenetically activating medium (EAM) which negatively enriches CTCs via the cancer hallmark of evading apoptosis. When isolated PBMCs are treated with the EAM, all non-malignant cells are killed by their functional apoptosis machinery, whereas all cancer derived malignant cells (CTCs) survive.
Tissue and organ of origin specific markers:
-
Conventional CTC based technologies infer the presence of CTC based on detection of EpCAM+, PanCK+ and CD45-cells. These technologies miss out on non-carcinoma cancers where these markers are known to be negative. In addition to overcoming the malignant v/s non-malignant conundrum by primary negative enrichment, TrucheckTM also incorporates evaluation of tissue organ of origin specific markers, which are known to be expressed in cancer cells and mostly absent in normal cells. TrucheckTM includes markers that cover various subtypes of carcinomas as well as markers specific for other cancer types such as gliomas, sarcomas and neuroendocrine tumours.
-
TrucheckTM uses multiplexed fluorescence immunocytochemistry (ICC) to evaluated multiple markers in a single run with unique fluorophore conjugated antibodies.
Order Trucheck™
How it works:
Select your test and proceed to check out
Select your chosen test and proceed to payment.
Booking the appointment
Our team will be in touch with you to book in your appointment at a time and location that suits you.
On the day
Our Dubai-Health-Authority (DHA) approved nurses will come to your agreed location and take a simple blood test (2x10ml).
Results
The samples will be sent to our laboratories on the same day, and your results will arrive approximately 10 days from the moment they arrive at our laboratories.
Select your Trucheck™ test
Single Organ - Breast Cancer Test
- checks for breast cancer
Learn More2,000.00 AED
Choose payment typeSingle Organ - Prostate Cancer Test
- checks for prostate cancer
Learn More2,000.00 AED
Choose payment typeSingle Organ - Colorectal Cancer Test
- checks for colon cancer
Learn More2,000.00 AED
Choose payment typeMultiple Organ Test
- checks for over 70 types of Cancer
Learn More4,600.00 AED
Choose payment typeFamily Multi Organ Test
- checks for over 70 types of cancer for 4 people above 18 years of age
Learn More16,800.00 AED
Choose payment typeAnnual Multi Organ Test Subscription
- annual check up for over 70 types of cancer (Minimum 3 Tests, Cancel any time)
Learn More3,950.00 AED / year
Choose payment typeCustom Plan
Please get in touchTrucheck in Publications
Akolkar D. et al.
Circulating ensembles of tumor-associated cells: A redoubtable new systemic hallmark of cancer (International Journal of Cancer, 2020).
-
Population - Cancers: 5.509 (Retrospective) • Asymptomatic: 10.625 (Prospective)
-
Parameters - Analyte: C-ETACs, CTCs • Proof of Concept Study
-
Performance Characteristics - Specificity: 96.4% (Asymptomatic) • Sensitivity: 89.5% (Retrospective)
Renade A. et al.
Hallmark Circulating Tumor-Associated Cell Clusters Signify 230 Times Higher One Year Cancer Risk. (AACR, 2021).
-
Population - Cancers: 5.509 (Retrospective) & 4.419 (P) • Benign: 324 (Prospective) • Asymptomatic: 10.625 (Prospective)
-
Parameters - Analyte: C-ETACs, CTCs • Assessment: Colony Detection Assay • Proof of Concept Follow-up Study
-
Performance Characteristics - Specificity: 97.5% (Benign) & 95.6% (Asymptomatic) • Sensitivity: 93.0% (Retrospective) & 93.0% (Prospective)
Gaya A. et al.
Evaluation of circulating tumor cell clusters for pan-cancer non-invasive diagnostic triaging. (ACS Journal, 2021).
-
Population - Cancers: 9.416 (Retrospective) & 6.025 (Prospective) • Benign: 700 • Asymptomatic: 13.919 (Prospective)
-
Parameters - Analyte: C-ETACs, CTCs • Assessment: Colony Detection Assay • Clinical Validation Study
-
Performance Characteristics - Specificity: 99.3% (Benign) & 100.0% (Asymptomatic) • Sensitivity: 85.2% (Retrospective) & 86.7% (Prospective)
We are here to help
If you have any questions, or wish to know more about any of our solutions, feel free to contact us, or review our FAQs.
Contact Support